Anti-DCAMKL3 (center) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

General description

A predominant CaMK subfamily, the CaMKI/CaMKIV family, is thought to play a significant role in the central nervous system. The CaMKIV-related kinases, doublecortin and CaM kinase-Like (DCAMKL)1, DCAMKL2, and DCAMKL3, contain kinase domains with an intermediate homology not only to CaMKI/CaMKIV but also to CaMKII. The DCAMKL proteins are highly expressed in the central nervous system of mice, in a neuron-specific fashion. DCAMKL1 lacks the doublecortin-like domain (Dx). In contrast, DCAMKL2 contains a full N-terminal Dx, while possesses only a partial and dysfunctional Dx. Despite a large similarity in the kinase domain, the DCAMKL proteins have an impact on CRE-dependent gene expression distinct from that of the related CaMKI/CaMKIV and CaMKII subfamilies.

Immunogen

DCAMKL3 (XP_047355, )This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human DCAMKL3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.